COVID-19 Resource Guide: SARS-CoV-2 genes and protein structure

Through the work of Sunil Thomas, PhD, a biomedical researcher at LIMR with expertise in vaccine design, this COVID-19 Resource Guide offers a compendium of the genes and protein structure of SARS-CoV-2. Given that COVID-19 will remain prevalent in society, the need remains urgent to develop second-generation vaccines that go beyond spike protein targeting to more fully prevent disease. This open-source site provides a ready source of molecular information for use by the scientific community.

Basic and preclinical research services

LIMR offers research services to research and affiliated faculty, incubating companies, and physicians throughout Main Line Health. Here, you will find information about various services.

Center for Human Antibody Technology

The Center for Human Antibody Technology (CHAT) is a core facility that uses a powerful human antibody cloning platform technology developed by LIMR's Scott Dessain, MD, PhD.

LIMR Chemical Genomics Center

The mission of LIMR Chemical Genomics Center (LCGC) is to advance medicinal discovery. We provide proprietary, uniquely diverse, drug-like chemical libraries and other resources that measurably improve the efficiency of high throughput screening (HTS) by 500 percent, and potentially reveal unexpected drug synergies that may otherwise not be discovered.

Biotechnology company incubator

Technology development at LIMR focuses on three main functions, including promoting the development and commercialization of discoveries through technology transfer, identifying new early-stage biotech companies and partnering with organizations in our community to increase awareness of LIMR and bring additional resources to our facility.

Assessment of drug candidates’ cardiac QT liability

Before new drug candidates can be tested in humans, it is critical to assess whether they will provoke an irregular heart rhythm. Gan-Xin Yan, MD, PhD, has pioneered a method called "wedge prep" that uses slices of heart tissue from the adult ventricle of a rabbit to deliver quick, accurate testing.

Office of Research Protections

The mission of the Office of Research Protections (ORP) is to forge a partnership with the Main Line Health research community to conduct safe and ethical research.